Density Functional Theory, Molecular Docking Study, and <i>In Vitro</i> Antioxidant Activity of Cinnamic Acid Isolated From <i>Piper betle</i> Leaves.

ABSTRACT: Piper betle is an edible plant known for its potent antioxidant activity. Among its phenolic constituents, cinnamic acid has been identified as a key compound contributing to this bioactivity. Although cinnamic acid is a well-known molecule, this study is the first to report its isolation from P. betle leaves, contributing valuable insights into the chemotaxonomy and phytochemical profile of the species. The aim of this research is to isolate cinnamic acid from the methanol extract of betel leaves and evaluate its antioxidant activity using DPPH and nonenzymatic mimic superoxide dismutase (mSOD) assays. Furthermore, computational analyses were performed using density functional theory (DFT) to assess the antioxidant properties, and molecular docking studies were conducted to

SUBMITTER: Tumilaar SG 

PROVIDER: S-EPMC12187441 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature