AT-rich interaction domain 5A facilitates axon regeneration through docking protein 6 in the peripheral nervous system.

ABSTRACT:

Background

Peripheral nerves are easily damaged in accidental trauma due to their shallow location. Compared to the limited regeneration of the central nerve, the peripheral nerve has a certain regenerative ability after injury. However, this ability is not sufficient to achieve functional recovery. To increase the rate of regeneration after nerve injury, increasing regeneration-associated gene expression by transcription factors in neurons is necessary.

Methods

Sciatic nerve crush animal models were generated in Sprague-Dawley rats. Bioinformatics analysis and quantitative real-time polymerase chain reaction were applied to detect gene expression; immunofluorescence staining and western blotting were applied to detect protein expression. The neurite outgrowth of cultured do

SUBMITTER: Ren Z 

PROVIDER: S-EPMC12187523 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature