S100A11 as an immune-related exosomal driver of colorectal cancer progression: a novel diagnostic biomarker.

ABSTRACT:

Background

Colorectal cancer (CRC) is a major cause of global cancer deaths, with increasing incidence among younger populations. Despite advancements in diagnostic and therapeutic strategies, early detection and effective treatment remain major challenges. Exosomes act as critical intercellular messengers, promoting cancer growth, immune escape, and chemotherapy resistance. This study aims to identify exosome-related biomarkers in CRC and elucidate the functional significance of S100A11 in tumor progression and immune regulation.

Methods

We integrated multi-cohort transcriptomic data from TCGA and GEO databases and applied a machine learning triad (LASSO-SVM-Random Forest) to identify robust exosomal biomarkers for CRC. Functional enrichment analysis, immune infiltration ev

SUBMITTER: Wang H 

PROVIDER: S-EPMC12187594 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature