A multi-domain lifestyle intervention in multiple sclerosis: a longitudinal observational study.

ABSTRACT:

Objective

To examine the effects of a multi-domain lifestyle intervention that advocated a Mediterranean style diet, and concurrently targeted physical activity, stress and sleep, on multiple sclerosis.

Methods

A longitudinal observational study investigating the effect of a multi-domain lifestyle intervention (i.e., diet, exercise, stress, and sleep management) at four timepoints: start run-in, start and stop 3-month intensive interval, and 3-month follow-up. The primary outcome (i.e., impact of multiple sclerosis on daily functioning) and secondary outcomes (i.e., quality of life, general health, multiple sclerosis-specific symptoms, and lifestyle factors) were analyzed using mixed models. Analyses were repeated among subgroups based on program compliance, body mass index,

SUBMITTER: Nauta IM 

PROVIDER: S-EPMC12187891 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature