Early-life microRNA signatures in cord blood associated with allergic rhinitis and asthma development.

ABSTRACT:

Background

MicroRNAs (miRNAs) are involved in the biological regulation of asthma and allergies.

Objective

We sought to investigate the association between cord blood miRNAs and the development of allergic rhinitis and early childhood asthma.

Methods

miRNAs were sequenced from cord blood of subjects participating in the Vitamin D Antenatal Asthma Reduction Trial. Multivariable miRNA differential expression analyses were performed to examine their association with physician-diagnosed asthma and allergic rhinitis by age 3 years as well as active asthma status at age 6 years. miRNA signatures were further investigated for their ability to induce human airway smooth muscle cell proliferation in vitro.

Results

In a cohort of 389 subjects, elevated cord blood express

SUBMITTER: Mirzakhani H 

PROVIDER: S-EPMC12187943 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature