Protein Associations With Alcohol Consumption and Genetic Risk for Alcohol-Related Sociomedical Conditions.

ABSTRACT: Studies investigating proteomic associations with alcohol consumption and the genetic links of these proteins to alcohol-related traits are scarce. The aims of our study were (1) to identify proteins associated with alcohol consumption and (2) to investigate the molecular pathways and genetics linking the identified proteins to alcohol consumption and related sociomedical conditions. We generated proteomic and genotypic data from blood samples of 387 Finnish twins (age range: 56-70) and calculated polygenic risk scores (PRSs) of eight alcohol-related traits: obesity, alcohol dependence, number of drinks per week, number of cigarettes per day, major depressive disorders (MDDs), schizophrenia, externalising behaviour and educational attainment. We identified 20 (out of 2321) proteins associa

SUBMITTER: Drouard G 

PROVIDER: S-EPMC12188143 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature