WNT signaling coordinately controls mouse limb bud outgrowth and establishment of the digit-interdigit pattern.

ABSTRACT: Self-organization, such as the emergence of a pattern from a homogenous state, is a fascinating property of biological systems. Early limb bud outgrowth and patterning in mice are controlled by a robust and self-regulatory signaling system, and initiation of the periodic digit-interdigit pattern appears to be under the control of a self-regulatory Turing system. Previous studies established the requirement of WNT and BMP signaling for both early limb bud and digit-interdigit morphogenesis, but the molecular changes underlying the transition from early limb bud signaling to the digit-interdigit patterning system remained unknown. Here, we have used small molecule inhibitors to rapidly but transiently block WNT signaling to identify the early transcriptional targets that are altered during d

SUBMITTER: Malkmus J 

PROVIDER: S-EPMC12188246 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature