Gene expression profiling of SPIN1 in gastric cancer: insights into tumorigenesis and potential therapeutic targets.

ABSTRACT:

Background

Gastric cancer (GC) is a prevalent malignant tumor globally, posing a significant threat to human health. The histone code reader Spindlin1 (SPIN1) has been implicated in tumorigenesis and tumor progression, however, the exact molecular mechanisms underlying these processes remain incompletely understood. The biological function and regulatory mechanisms of SPIN1 in GC remain ambiguous. This study aims to investigate the regulatory mechanisms of SPIN1 in the pathogenesis and progression of GC, as well as to identify genes closely associated with SPIN1 and potential biomarkers.

Methods

Gene expression profiles from 375 patients diagnosed with gastric cancer (GC) and 32 control subjects were obtained from the TCGA-STAD database. Our study examined the relationships

SUBMITTER: Lv BB 

PROVIDER: S-EPMC12188309 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature