Prior Expectations of Volatility Following Psychotherapy for Delusions: A Randomized Clinical Trial.

ABSTRACT:

Importance

Persecutory delusions are common, distressing, and difficult to treat. Testing computational neuroscience models of delusions can identify new therapeutic targets.

Objective

To determine whether change in delusion severity is associated with a corresponding change in volatility priors and brain activation estimated during a belief updating task.

Design, setting, and participants

This randomized clinical trial was conducted from April 9, 2021, to December 5, 2023, within the Vanderbilt University Medical Center Psychiatric Hospital and at a community mental health center in Nashville, Tennessee. Participants were adults (aged between 18 and 65 years) with schizophrenia spectrum or delusional disorder and an active, persistent (≥3 months) persecutory delusion

SUBMITTER: Sheffield JM 

PROVIDER: S-EPMC12188364 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature