Structural control of dynamic covalent cages: kinetic <i>vs.</i> thermodynamic assembly and PFAS removal from water.

ABSTRACT: Dynamic covalent chemistry is a powerful tool to synthesise complex structures from simple building blocks. However, even minor variations in the numerous parameters governing self-assembly can drastically influence the size and structure of the resulting assemblies. Herein, we report the selective formation of three cages belonging to the low-symmetry Tri² ₂Tri² cage topology for the first time, using highly symmetric tritopic building blocks, confirmed by single-crystal X-ray (SC-XRD) analysis. Fluorinated and non-fluorinated aldehydes were combined with two amines differing in their degree of structural flexibility. Applying either kinetic or thermodynamic control through solvent selection allowed for the selective synthesis of either the low-symmetry Tr

SUBMITTER: Pausch T 

PROVIDER: S-EPMC12188467 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature