Defining neuronal responses to the neurotropic parasite <i>Toxoplasma gondii</i>.

ABSTRACT: A select group of pathogens infects neurons in the brain. Prior dogma held that neurons were "defenseless" against infecting microbes, but many studies suggest that neurons can mount anti-microbial defenses. However, a knowledge gap in understanding how neurons respond in vitro and in vivo to different classes of microorganisms remains. To address this gap, we compared a transcriptional data set derived from primary neuron cultures (PNCs) infected with the neurotropic intracellular parasite Toxoplasma gondii with a data set derived from neurons injected with T. gondii protein in vivo. These curated responses were then compared to the transcriptional responses of PNCs infected with the single-stranded RNA viruses, West Nile virus or Zika virus. These analy

SUBMITTER: Johnson HJ 

PROVIDER: S-EPMC12188731 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature