Genome mining identifies a diversity of natural product biosynthetic capacity in human respiratory <i>Corynebacterium</i> strains.

ABSTRACT: Corynebacterium species, integral to the healthy human upper respiratory tract (URT) microbiota, remain underexplored in microbial genomics for their potential to promote respiratory health and exclude pathobionts. This genomic study investigated the diversity and capacity for natural product synthesis within these species, as indicated by their biosynthetic gene clusters (BGCs). We aimed to map and quantify the BGC diversity in a contemporary collection of Corynebacterium strains, representative of their prevalence in the respiratory microbiota, and to elucidate intra- and interspecies variation in BGC content. The outcomes of this research could reveal key factors in maintaining the ecological balance of the upper respiratory tract and identify novel antimicrobial agents ta

SUBMITTER: Cunningham AL 

PROVIDER: S-EPMC12188740 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature