Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome.

ABSTRACT: Mitochondria transfer is a recently described phenomenon in which donor cells deliver mitochondria to acceptor cells^1-3. One possible consequence of mitochondria transfer is energetic support of neighbouring cells; for example, exogenous healthy mitochondria can rescue cell-intrinsic defects in mitochondrial metabolism in cultured ρ⁰ cells or Ndufs4^-/- peritoneal macrophages^4-7. Exposing haematopoietic stem cells to purified mitochondria before autologous haematopoietic stem cell transplantation allowed for treatment of anaemia in patients with large-scale mitochondrial DNA mutations^8,9, and mitochondria transplantation was shown to minimize ischaemic damage to the heart^10-12, brain^13-15 and limbs¹

SUBMITTER: Nakai R 

PROVIDER: S-EPMC12188917 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature