Functional and Genetic Insights into the Role of the <i>NR4A1</i> Gene in the Litter Size of the Shaanbei White Cashmere Goat.

ABSTRACT: Nuclear receptor subfamily 4 group A member 1 (NR4A1) plays a crucial role in regulating various physiological processes. As gene mining for reproductive traits is essential, this study aimed to investigate the mRNA expression, genetic variation, and association of the NR4A1 gene with goat litter size. We examined the mRNA expression levels of the NR4A1 gene in eight different tissues of female Shaanbei White Cashmere (SBWC) goats (n = 6). Then, a novel 11-bp insertion/deletion (InDel) variant was genotyped in 1136 SBWC goats, 87 SNPs were identified through resequencing (n = 120), and selection signal analysis was undertaken. The NR4A1 gene was expressed in all examined tissues, including the ovary and the oviduct, suggesting its role in goat repr

SUBMITTER: Areb E 

PROVIDER: S-EPMC12189067 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature