Integrative Analysis of Neutrophil-Associated Genes Reveals Prognostic Significance and Immune Microenvironment Modulation in Cervical Cancer.

ABSTRACT: Background: Tumour-associated neutrophils play an important role in tumour progression and immunomodulation. However, the prognostic significance and immunological implications of neutrophil-associated genes (NAGS) in cervical cancer remain poorly defined. Methods: We analyzed neutrophil infiltration and its correlation with gene expression in TCGA cervical cancer data using immune deconvolution. NAGS were identified via correlation and enrichment analysis. A prognostic model was constructed using Cox and LASSO regression and validated in the GSE30759 cohort. Kaplan-Meier analysis, ROC curves, and multivariate Cox regression were used to assess prognostic performance. The model's association with the tumor immune microenvironment and immunotherapy response was further analyze

SUBMITTER: Hu T 

PROVIDER: S-EPMC12189475 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature