<i>Periplaneta americana</i> (L.) Extract PAS840 Promotes Ischemic Stroke Recovery by Inhibiting Inflammasome Activation.

ABSTRACT: Ischemic stroke (IS) is a high-mortality, multi-complication cardiovascular disease. Reducing brain injury and promoting neuronal repair after IS onset remain important challenges for current treatments. Our team previously found that PAS840, an extract from Periplaneta americana (L.), protects nerve function; this study further uses LC-MS/MS and peptidomics to analyze PAS840's components and network pharmacology to predict its ischemic stroke (IS) therapeutic targets. We then employed Transwell, a biochemical kit, real-time quantitative polymerase chain reaction (RT-qPCR), and transcriptomics to investigate PAS840's effects on migration ability, oxidative stress levels, and cellular pathways in mouse microglial cells (BV-2) following oxygen-glucose deprivation/reoxygenation (OGD/R)

SUBMITTER: Yang X 

PROVIDER: S-EPMC12189569 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature