Single-Cell Transcriptomics Unveils the Mechanistic Role of FOSL1 in Cutaneous Wound Healing.

ABSTRACT: Background: The skin, a complex organ vital for protecting the body against environmental challenges, undergoes a multifaceted wound healing process involving hemostasis, inflammation, proliferation, and remodeling. The transcription factor FOSL1 has been implicated in various cellular processes crucial for wound healing, including cell cycle regulation, differentiation, and apoptosis. We hypothesize that FOSL1 is a key regulator of wound healing processes. Objective: The objective of this study was to investigate the role of FOSL1 in cutaneous wound healing, identify the core signaling pathways involved, and assess FOSL1's potential as a therapeutic target. Method: We utilized datasets from the Gene Expression Omnibus (GEO) and applied the 'limma' package to discern d

SUBMITTER: Meng J 

PROVIDER: S-EPMC12189721 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature