Characteristics of Intestinal Microbiota and Host Gene Regulation in <i>Coilia nasus</i> Responding to Stress.

ABSTRACT: Transport stress in aquaculture poses significant challenges to fish health by inducing oxidative stress and intestinal damage. This study investigated the effects of transport stress on intestinal microbiota, host gene regulation, and metabolic responses in Coilia nasus. The fish were subjected to simulated transport conditions, followed by an analysis of their intestinal antioxidant capacity, inflammatory factors, transcriptome sequencing, metagenomic profiling, and metabolomic assays. The results revealed that transport stress significantly suppressed antioxidant enzyme activities (e.g., catalase, superoxide dismutase, glutathione peroxidase) and elevated oxidative damage (malondialdehyde, lipid peroxidation) alongside upregulating pro-inflammatory cytokines. The transcriptomic a

SUBMITTER: Gao J 

PROVIDER: S-EPMC12189889 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature