Forecasting drug resistant HIV protease evolution.

ABSTRACT: Protease inhibitors (PIs) target the protease (PR) enzyme to suppress viral replication. Their efficacy in human immunodeficiency virus treatment is compromised by the emergence of drug-resistant strains. Therefore, forecasting drug-resistance during viral evolution would help in the design of effective treatment strategies. We develop a probabilistic large-deviation model to infer epistatic interactions in genotypes observed in different treatment regimens and compute transition probabilities of point-mutations conditioned on the genotype and the treatment regimen. We simulate stochastic evolutionary paths weighted by such transition probabilities and show that low probable mutations are required for the viral population to evolve to diverse fit genotypes. We train classification models u

SUBMITTER: Aggarwal M 

PROVIDER: S-EPMC12190175 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature