Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice.

ABSTRACT:

Background

Ethanol metabolism is intimately linked with the physiological and behavioral aspects of ethanol consumption. Ethanol is mainly oxidized by alcohol dehydrogenase (ADH) to acetaldehyde and further to acetate via aldehyde dehydrogenases (ALDHs). Understanding how ethanol and its metabolites work together to initiate and drive continued ethanol consumption is crucial for identifying interventions for alcohol use disorder (AUD). Therefore, the goal of our study was to determine how ADH1, which is mainly peripherally-expressed and metabolizes >90% of ingested ethanol, modulates ethanol metabolite distribution and downstream behaviors.

Methods

Ethanol consumption in drinking-in-the-dark (DID) and two-bottle choice (2BC) drinking paradigms, ethanol metabolite concentrati

SUBMITTER: Mackowiak B 

PROVIDER: S-EPMC12190315 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature