Donor-Specific Digital Twin for Living Donor Liver Transplant Recovery.

ABSTRACT: Liver resection initiates a meticulously coordinated hyperplasia process characterized by regulated cell proliferation that drives liver regeneration. This process concludes with the complete restoration of liver mass, showcasing the precision and robustness of this homeostasis. The remarkable capacity of the liver to regenerate rapidly into a fully functional organ has been crucial to the success of living donor liver transplantation (LDLT). In healthy livers, hepatocytes typically remain in a quiescent state (G0). However, following partial hepatectomy, these cells transition to the G1 phase to re-enter the cell cycle. Surgical resection induces various stresses, including physical injury, altered blood flow, and increased metabolic demands. These all trigger the activation and suppressi

SUBMITTER: Halder S 

PROVIDER: S-EPMC12190347 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature