Structural Insights into Cir-mediated Killing by the Antimicrobial Protein Microcin V.

ABSTRACT: Drug-resistant bacterial infections have become a high-priority concern in the global healthcare landscape. Novel treatments for such infections are needed, but can be especially difficult to develop for Gram-negative species owing to the need to traverse the outer membrane to reach targets beneath. A promising solution is found in natural antibiotics such as albomycin, which can bind outer membrane siderophore receptors and co-opt them for import into the periplasm. Exploring this and similar mechanisms may open avenues for antibiotic development. An underappreciated class of natural antibiotics are the microcins, which are small antimicrobial proteins secreted by certain bacterial species as a means of inter-species competition. Once secreted, the microcins bind specific outer-membrane r

SUBMITTER: Maurakis SA 

PROVIDER: S-EPMC12190408 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature