The Utility of Maternal Blood S100B in Women with Suspected or Established Preeclampsia-A Systematic Review.

ABSTRACT:

Purpose

Preeclampsia is a serious pregnancy complication without curative treatment. The central nervous system (CNS) is affected in severe cases of preeclampsia. Until now, no biomarker or other predictive method has been established for predicting severe CNS injury, including the development of eclampsia and/or long-term complications. In this systematic review, we aimed to investigate the association between maternal blood (serum or plasma) S100B levels and preeclampsia, focusing on its predictive value and correlation with the severity of the disease, with a particular focus on neurological symptoms.

Methods

A search of online databases, including Medline via PubMed, Scopus databases, and Web of Science, was performed based on the PRISMA guidelines for systematic reviews

SUBMITTER: Karampas G 

PROVIDER: S-EPMC12190636 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature