Analysis of Novel DNA Adducts Derived from Acetaldehyde.

ABSTRACT: Alcohol consumption is a known risk factor for esophageal and liver cancers. Recently, it was reported that mutation signatures characterized by T:A to C:G mutations (SBS16), which are suggested to be associated with alcohol intake, are frequently detected in esophageal, liver, and stomach cancers among the Japanese population. However, the scientific evidence linking alcohol consumption to SBS16 remains lacking. Acetaldehyde (AA), a carcinogenic metabolite of alcohol, is considered a key contributor to alcohol-related cancer development. Although the guanine adducts associated with alcohol exposure have been reported as part of its carcinogenic mechanism, an adenine adduct, N⁶-ethyl-deoxyadenosine (N⁶-ethyl-dA), a potential contributor to the SBS16 muta

SUBMITTER: Betsuyaku Y 

PROVIDER: S-EPMC12190651 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature