Evolution of gene order in prokaryotes is driven primarily by gene gain and loss.

ABSTRACT: Evolution of bacterial and archaeal genomes is highly dynamic including extensive gene gain via horizontal gene transfer and gene loss as well as different types of genome rearrangements, such as inversions and translocations, so that gene order is not highly conserved even among closely related organisms. We sought to quantify the contributions of different genome dynamics processes to the evolution of the gene order relying on the recently developed "jump" model of gene translocation. The jump model has been completely solved analytically and provides the exact distribution of syntenic gene block lengths (SBL) in compared genomes based on gene translocations alone. Comparing the SBL distribution predicted by the jump model with the distributions empirically observed for multiple groups o

SUBMITTER: Brezner S 

PROVIDER: S-EPMC12190745 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature