The Infraslow Fluctuation of Sigma Power During Sleep in Young Individuals with Schizophrenia.

ABSTRACT: A reduction in sleep spindles, a major electrophysiological characteristic of Non-Rapid Eye Movement sleep, has been suggested as a potential biomarker of schizophrenia. While research has primarily focused on the spindle quantity, recent studies have begun to explore their temporal dynamics throughout the night. In healthy individuals, sleep spindles fluctuate on an infraslow ~50-second timescale, alternating between phases of high and low spindle activity. This fluctuation is referred to as the infraslow fluctuation of sigma power (ISFS), which is modulated by noradrenergic activity from the locus coeruleus and linked to the organization of arousal and memory reactivation processes during sleep. Given the known deficit in sleep spindles, dysregulation of noradrenergic activity, and impai

SUBMITTER: Dimitriades ME 

PROVIDER: S-EPMC12190756 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature