African ancestry-enriched variants in the <i>GATM</i> gene are associated with elevated serum creatinine levels.

ABSTRACT:

Background

Serum creatinine (Scr) levels are routinely used to estimate kidney function and health. Individuals of African ancestry have higher Scr levels - controlling for differences in age, sex, size, kidney function, and disease status - compared to individuals from other ancestral backgrounds. The reason for this difference is unknown. We hypothesized that there may be genetic variants found at relatively high frequency in African ancestry groups (African ancestry-enriched variants) that are associated with elevated Scr levels African ancestry individuals.

Methods

Our study sample is made up of participants from the All of Us Research Program. We used whole genome sequence data to estimate genetic ancestry for All of Us participants and selected a cohort of 18,979 parti

SUBMITTER: Sharma S 

PROVIDER: S-EPMC12191081 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature