The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders.

ABSTRACT: Psychiatric disorders display high levels of comorbidity and genetic overlap^1,2. Genomic methods have shown that even for schizophrenia and bipolar disorder, two disorders long-thought to be etiologically distinct³, the majority of genetic signal is shared⁴. Furthermore, recent cross-disorder analyses have uncovered over a hundred pleiotropic loci shared across eight disorders⁵. However, the full scope of shared and disorder-specific genetic basis of psychopathology remains largely uncharted. Here, we address this gap by triangulating across a suite of cutting-edge statistical genetic and functional genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders (1,056,201 cases). Our analyses identify and characterize five underl

SUBMITTER: Grotzinger AD 

PROVIDER: S-EPMC12191084 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature