Spatially separated epithelium-associated and lamina propria neutrophils present distinct functional identities in the inflamed colon mucosa.

ABSTRACT: Inflammatory Bowel Disease (IBD) features en masse neutrophil (PMN) infiltration of the colon tissue, where PMNs occupy spatially distinct niches, including the lamina propria mucosa (LPNs) and the crypt epithelium (epithelium-associated neutrophils or EANs). Spatial PMN localization is currently used as a clinical disease scoring parameter, and EAN presence has been correlated with disease severity prognosis and reduced response to therapy. Surprisingly, although PMN heterogeneity and their clinical relevance in IBD is now well-recognized, localization-driven PMN specialization has not been investigated. We found that following initial PMN influx during the active disease phase, EANs were near-completely resolved in both UC remission patients and in murine colitis, whereas LPNs persisted

SUBMITTER: Yalom LK 

PROVIDER: S-EPMC12191385 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature