A Theoretical and Practical Analysis of Membrane Protein Genes Altered in Neutrophils in Parkinson's Disease.

ABSTRACT: Parkinson's disease (PD) is a major health concern, with no accurate or early diagnostic test available for most patients. Chronic inflammation is a recognized contributor to PD pathogenesis; thus, membrane proteins of inflammatory cells such as neutrophils present an accessible target for detecting early molecular changes. In this study, we conducted a theoretical analysis using the GSE99039 database to identify differentially expressed genes (DEGs) in leukocytes from PD patients. From this, we selected nine top candidates for digital polymerase chain reaction (dPCR) analysis in isolated neutrophils from nine PD patients and nine matched controls. Our results revealed significant upregulation of ORAI3 and CLCN2. Unexpectedly, both ACTB (β-actin) and SNCA

SUBMITTER: Lopez Pintor A 

PROVIDER: S-EPMC12191767 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature