Biomarkers of Endothelial Damage and Disease Severity in COVID-19 Patients.

ABSTRACT: The severe outbreak of SARS-CoV-2, the etiological agent of COVID-19, has precipitated the development of vaccines and antiviral therapeutics. However, it remains a significant public health concern. This study investigated the association between disease severity, biomarkers of coagulation, and endothelial damage, including P-selectin, thrombomodulin, PAI, von Willebrand antigen (VWF: Ag) and von Willebrand factor ristocetin cofactor (VWF: RCo). A cross-sectional, observational study was conducted in a cohort of 90 adult COVID-19 patients (≥18 years), categorized into three groups: ICU-hospitalized, non-ICU hospitalized, and asymptomatic non-hospitalized (outpatient). In these groups, biomarkers, including PAI-1, TM, and P-selectin, were assessed using enzyme-linked immunosorbent assay (E

SUBMITTER: Tsiatsiou P 

PROVIDER: S-EPMC12191880 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature