Gut Microbiota Differences in Infants with Cow-Milk-Induced Allergic Proctocolitis: A Comparative Cross-Sectional Study.

ABSTRACT: Background: Cow-milk-induced allergic proctocolitis (CMIAP) is a non-IgE-mediated food hypersensitivity that often resolves spontaneously but may predispose infants to IgE-mediated allergies and eosinophilic gastrointestinal disorders. Understanding its pathophysiology is crucial for microbiota-based interventions. Methods: We enrolled 32 exclusively breastfed infants-16 with confirmed cases of CMIAP and 16 age-matched healthy controls. The cohorts were sex-balanced (8 F/8 M), term-born (gestational age ± SD: 40 ± 1.2 vs. 39 ± 1.3 weeks), vaginally delivered, and sampled at a mean age of 2.0 ± 0.44 months (range 1.5-3.0) vs. 2.4 ± 0.66 months (range 1.5-3.5). Faecal samples underwent 16S rRNA gene sequencing on the Illumina NovaSeq platform, with diversit

SUBMITTER: Haytoglu Z 

PROVIDER: S-EPMC12191891 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature