Active Protein Network Analysis Reveals Coordinated Modules and Critical Proteins Involving Extracellular Electron Transfer Process.

ABSTRACT:

Background

Traditional differential expression analysis typically identifies genes with varying expression levels and uses them to construct networks. However, this approach often fails to capture changes in gene interactions that occur at constant gene expression levels.

Objectives

To address this limitation, this study investigated the dynamics of protein interactions through active networks under various conditions, focusing on Shewanella oneidensis MR-1, a model electroactive microorganism.

Methods

We constructed both condition-specific and time-course active protein networks using gene expression and protein interaction data from S. oneidensis MR-1.

Results

Our analysis revealed several functional modules that were active and well-coordinated

SUBMITTER: Ding D 

PROVIDER: S-EPMC12191902 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature