<i>PCLO</i> Is Associated with Tumor Mutational Burden and Immunity in Patients with Oral Squamous Cell Carcinoma.

ABSTRACT: To determine predictive biomarkers for prognosis by analyzing the association between tumor mutational burden (TMB) and mutant genes in patients with oral squamous cell carcinoma (OSCC) and to validate PCLO as an OSCC predictive biomarker, OSCC genetic mutation data were downloaded from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) database. Immune cell infiltration analysis and visualization were performed using R software. The relationships between overall survival (OS) and mutant genes or clinicopathological factors were investigated by Kaplan-Meier analysis and Cox regression analysis, respectively. Gene set enrichment analysis (GSEA) was used to explore the associations between mutant genes and functional pathways. Immunohistochemistry was

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12192405 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature