Optimizing the use of Ki-67 proliferative index as a prognostic biomarker in meningiomas using digital analysis.

ABSTRACT:

Objective

Ki-67 immunohistochemistry is widely used as a prognostic marker in meningiomas, but visual estimations tend to be imprecise. Whether the average Ki-67 over an entire slide, a particular block, or areas of high staining (hotspots) is prognostic for recurrence-free survival (RFS) and overall survival (OS) is unknown. This study aimed to generate evidence-based recommendations for the optimal use of Ki-67 immunohistochemistry in the workup of meningiomas.

Methods

All tissue blocks from a retrospective cohort of 221 patients with primary meningioma (141 WHO grade 1, 64 WHO grade 2, 16 WHO grade 3) were immunostained for Ki-67 and scanned using automated digital analysis software. QuPath was used to quantify the average Ki-67 proliferation index per slide as well as th

SUBMITTER: Thirunavu V 

PROVIDER: S-EPMC12192485 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature