Redox response feature and mechanism of Arf1 and their implications for those of Ras and Rho GTPases.

ABSTRACT: The small GTPases ADP-ribosylation factor (Arf), Ras, and Rho cycle between their active GTP-bound and inactive GDP-bound forms. Their regulatory proteins or inorganic redox agents regulate this cycle, which in turn regulates various important cell signals. Unlike regulatory protein-based regulation, redox-mediated regulation that occurs through the redox response of small GTPases to a redox agent is feasible only when the small GTPases are redox sensitive. The known redox-sensitive small GTPases including Ras and Rho have the reactive Cys in their unique redox motif. This study is the first to show the redox-response feature of Arf1 linked to a novel redox-sensitive Cys in the Arf-specific redox motif and its importance for cell functions. The Arf1 redox motif is currently the simplest fo

SUBMITTER: Johnson HE 

PROVIDER: S-EPMC12192700 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature