Network-targeted transcranial magnetic stimulation (TMS) for mild cognitive impairment (MCI).

ABSTRACT:

Background

Transcranial magnetic stimulation (TMS) is a promising non-pharmacological intervention for treatment of mild cognitive impairment (MCI) and early Alzheimer's disease (AD). Yet, we know little about precisely where stimulation would be ideal to improve cognitive function.

Objective

To examine the network functional connectivity (fc) characteristics of prefrontal and parietal stimulation sites, given that these sites have led to improved cognitive function in TMS studies involving MCI-AD and unimpaired participants.

Methods

Resting-state functional MRI data were acquired from 32 MCI participants at the baseline visit of an ongoing TMS trial and used to compute connectivity with prefrontal and parietal stimulation locations, selected on the basis of previous

SUBMITTER: Taylor JL 

PROVIDER: S-EPMC12192757 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature