Flaxseed Extracts Impact the Cellular Structure of a Keratinocyte Model for Oral Lichen Planus-A Preliminary Study.

ABSTRACT: Oral inflammation and the immune response are distinct but related processes where Linum usitatissimum L., fam. Linaceae represents a possible use for localized relief. Oral lichen planus (OLP) is an oral potentially malignant disorder (OPMD) with an inflammatory background that mainly affects post- and peri-menopausal women. The presented methodology was threefold. Firstly, the plant extracts were made from flaxseeds of selected cultivars (Szafir [SZ] and Jantarol [JA]) containing plant lignans. In silico docking affinity was performed to verify the beta and alpha estrogen receptors of keratinocytes' (ERα and ERβ) affinity for lignans from the plant extracts. Lastly, tests using living keratinocyte cell lines were performed. Adding the studied extracts from two cultivars of flaxsee

SUBMITTER: Dus-Ilnicka I 

PROVIDER: S-EPMC12192927 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature