Impact of monitor unit optimization in volumetric modulated arc therapy planning for nasopharyngeal carcinoma.

ABSTRACT:

Purpose

To evaluate the impact of monitor units (MUs) optimization on volumetric modulated arc therapy (VMAT) plan for nasopharyngeal carcinoma (NPC).

Methods

Twenty-one NPC patients were retrospectively analyzed. Dual-arc VMAT plan were designed using photon optimization algorithms without the monitor unit objective (MUO) tool, denoted as the base plan. Each base plan was re-optimized with the MUO tool with the Maximum MU parameter set to 30% of the base plans' total MUs and Strength parameters set to 50, 80, and 100, generating plans S50, S80, and S100. Target and organ-at-risk (OAR) dose distributions, MUs, beam delivery time, and gamma passing rates were compared between re-optimized and base plans. Statistical analysis was performed using SPSS 17.0 (paired t-tests; sign

SUBMITTER: Zeng H 

PROVIDER: S-EPMC12193012 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature