The Prognostic Value of the Hedgehog Signaling Pathway in Ovarian Cancer.

ABSTRACT: The hedgehog pathway is a major regulator of cell growth and differentiation during embryogenesis and early development. The literature suggests that variations in this pathway's genes play a role in tumor progression and response to therapy. This study aimed to assess the correlation between the expression levels of selected genes of this pathway and the progression-free and overall survival of ovarian cancer patients. Using the database Kaplan-Meier plotter, which includes the gene expression and survival data of 1565 ovarian cancer patients, higher expression levels of the genes SHH, PTCH1, PTCH2, and GLI1 displayed better survival correlations, while GLI, GLI3, and SUFU correlated with adverse outcomes. Further dissection revealed a diff

SUBMITTER: Salman ND 

PROVIDER: S-EPMC12193027 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature