Chromosome-Contiguous <i>Ancylostoma duodenale</i> Reference Genome from a Single Archived Specimen Elucidates Human Hookworm Biology and Host-Parasite Interactions.

ABSTRACT: Soil-transmitted helminths (STHs) are parasitic nematodes that infect humans, particularly in tropical and subtropical regions, where they contribute substantially to neglected tropical diseases (NTDs). Among them, hookworms (Ancylostoma duodenale, Necator americanus and Ancylostoma ceylanicum) cause substantial morbidity, leading to anaemia, malnutrition, and developmental impairment. Despite the global impact of hookworm disease, genomic research on A. duodenale has lagged behind that of other hookworms, limiting comparative and molecular biological investigations. Here, we report the first chromosome-level reference genome of A. duodenale, assembled from a single adult specimen archived in ethanol at -20 °C for more than 27 years. Using third-generatio

SUBMITTER: Young ND 

PROVIDER: S-EPMC12193031 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature