Proteomic Profiling Identifies MARCO in Extracellular Vesicles, as a Potential Biomarker for Leishmaniasis in HIV Co-Infection.

ABSTRACT: Leishmania is an intracellular protozoan parasite that causes leishmaniasis, a disease prevalent in 97 countries. Co-infection with HIV increases susceptibility to visceral leishmaniasis (VL), accelerating HIV's progression to AIDS. Managing VL in HIV-infected individuals is challenging due to atypical presentations and limited therapeutic responses, highlighting the need to develop new disease management strategies. Extracellular vesicles (EVs) hold great promise for this goal as they can be used for a higher understanding of biological processes and biomarker discovery. In this context, a proteomic analysis was carried out from plasma-EVs of an HIV/VL patient over two years and compared to HIV and healthy controls. The analysis confirmed classical EV markers but showed limited det

SUBMITTER: Costa I 

PROVIDER: S-EPMC12193235 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature