Tannic Acid-Loaded Gellan Gum Hydrogels Reduce In Vitro Chemokine Expression in Oral Cells.

ABSTRACT: Tannic acid (TA), a natural polyphenol with antiphlogistic and crosslinking properties, is a versatile component of hydrogel that can be delivered to inflammatory sites in oral applications. However, the impact of TA dampening an inflammatory response in oral cells remains to be shown. We, therefore, established a bioassay where chemokine expression is induced by exposing gingival fibroblasts and HSC2 oral squamous carcinoma cells to IL1β and TNFα. Additionally, gingival fibroblasts were stimulated with saliva and poly I:C HMW to trigger chemokine production. Our findings demonstrate that TA effectively reduced the expression of CXCL1, CXCL2, CXCL8, and CXCL10-in gingival fibroblasts and HSC2 cells-without affecting cell viability. This effect was further confirmed by immunoassays f

SUBMITTER: Dos Santos Sanches N 

PROVIDER: S-EPMC12193560 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature