New Bioactive Polyketides from the Mangrove-Derived Fungus <i>Daldinia eschscholzii</i> HJX1P2.

ABSTRACT: Three new naphthalene-chroman dimer derivatives, daldinaphchromes A-C (1-3), two new chroman derivatives, daldichromes A (5) and B (6), along with five known compounds (4, 7-10) were isolated from the mangrove-derived fungus Daldinia eschscholzii HJX1P2. Their structures and stereochemistries were elucidated through detailed NMR and MS analyses, calculated electronic circular dichroism, and comparison with previously reported data. Compound 1 demonstrated inhibitory effects on nitric oxide (NO) production in LPS-induced RAW 264.7 cells, with an IC₅₀ value of 62.9 µM, and more effectively suppressed the expression of interleukin (IL)-6 than dexamethasone. A further mechanistic study suggested that 1 could prohi

SUBMITTER: Yu M 

PROVIDER: S-EPMC12193800 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature