The Dysregulation of Tuning Receptors and Transcription Factors in the Antennae of <i>Orco</i> and <i>Ir8a</i> Mutants in <i>Aedes aegypti</i> Suggests a Chemoreceptor Regulatory Mechanism Involving the MMB/dREAM Complex.

ABSTRACT: Olfaction has been extensively studied in the yellow fever mosquito, Aedes aegypti. This species uses its sense of smell to find blood hosts and other resources, contributing to its impact as a vector for human pathogens. Two major families of protein-coding genes, the odorant receptors (Ors) and the ionotropic receptors (Irs), provide the mosquito with sensitivities to distinct classes of volatile compounds in the antennae. Individual tuning receptors in both families require co-receptors for functionality: Orco for all Ors, and Ir8a for many Irs, especially ones that are involved in carboxylic acid detection. In Drosophila melanogaster, disruptions of Orco or Ir8a impair receptor function, tuning receptor expression, a

SUBMITTER: Cooke MM 

PROVIDER: S-EPMC12193925 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature