Investigating working memory updating processes of the human subcortex using 7T MRI.

ABSTRACT: A growing body of research suggests that dopamine is involved in working memory updating and that the striatum takes up a critical role in the subprocess of working memory gating . In this study, we investigated subcortical - in particular, possible dopaminergic - involvement in working memory updating subprocesses using the reference-back task and ultrahigh field 7 Tesla functional magnetic resonance imaging (fMRI). Using a scanning protocol optimized for BOLD sensitivity in the subcortex, we found no evidence of subcortical activation during working memory gate opening, predominantly activations in frontoparietal network regions, which challenges the idea of a striatal gating mechanism. However, during gate closing, subcortical activation was observed. Furthermore, a ready-to-update mode

SUBMITTER: Trutti AC 

PROVIDER: S-EPMC12194129 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature