Distinct adaptation and epidemiological success of different genotypes within <i>Salmonella enterica</i> serovar Dublin.

ABSTRACT: Salmonella Dublin is a host-adapted, invasive nontyphoidal Salmonella (iNTS) serovar that causes bloodstream infections in humans and demonstrates increasing prevalence of antimicrobial resistance (AMR). Using a global dataset of 1303 genomes, coupled with in vitro assays, we examined the evolutionary, resistance, and virulence characteristics of S. Dublin. Our analysis revealed strong geographical associations between AMR profiles and plasmid types, with highly resistant isolates confined predominantly to North America, linked to IncC plasmids co-encoding AMR and heavy metal resistance. By contrast, Australian isolates were largely antimicrobial-susceptible, reflecting differing AMR pressures. We identified two phylogenetically distinct Australian lineages, ST10 and S

SUBMITTER: Sia CM 

PROVIDER: S-EPMC12194135 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature