Astragaloside IV combined with quercetin attenuates silica-induced pulmonary fibrosis by promoting autophagy and suppressing pyroptosis.

ABSTRACT:

Background

Silicosis, a prevalent occupational disease caused by exposure to silica particles, currently lacks effective treatment. Traditional Chinese medicine (TCM), with its millennia of clinical application, offers potential therapeutic solutions. This study aimed to investigate the therapeutic effects of astragaloside IV (ASV) combined with quercetin (QUE) in silicosis, particular focus on their possible mechanisms involving autophagy modulation and pyroptosis regulation.

Methods

Rat silicosis models were established through silica particle exposure to evaluate the therapeutic effects of ASV and QUE coadministration over 28 days. We assessed pulmonary inflammatory and fibrotic markers while simultaneously analyzing autophagy and pyroptosis-related indicators to elucidat

SUBMITTER: Zhu W 

PROVIDER: S-EPMC12194182 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature