The role of senescence-related hub genes correlating with immune infiltration in type A aortic dissection: Novel insights based on bioinformatic analysis.

ABSTRACT:

Background

Stanford type A aortic dissection (AAD) is a fatal disease that confers extremely high morbidity and mortality. Cellular senescence, characterized by a permanent cell cycle arrest, has been implicated in the onset and progression of cardiovascular disease and immune cell infiltration has been observed in the aortic walls of dissected specimens. However, the precise mechanisms through which senescent cells interact with immune infiltration to contribute to the development and progression of AAD remain unclear.

Methods

Cellular senescence-related genes (SRGs) were identified via the CellAge database. Patient and normal control datasets (GSE52093 and GSE190635) were retrieved from the Gene Expression Omnibus (GEO) database, with GSE190635 serving as the validation se

SUBMITTER: He W 

PROVIDER: S-EPMC12194205 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature