Characterization of Biofilm Formation by the Dermatophyte <i>Nannizzia gypsea</i>.

ABSTRACT: Dermatophytosis is a fungal infection that affects the skin, hair, and nails, impacting approximately 25% of the global population. Nannizzia gypsea is a geophilic fungus that can cause infections in humans and animals. Several studies have been conducted regarding its virulence, or ability to cause disease. This species may produce keratinolytic enzymes and form biofilms, which can increase resistance to treatment. Thus, this study focuses on investigating the biofilm formation of N. gypsea isolated from canine dermatophytosis using an ex vivo hair model, its biofilm extracellular matrix macromolecular contents, and the expression of genes involved in the colonization of keratinized surfaces. The biofilm was analyzed for metabolic activity using the XTT reduction assay, crys

SUBMITTER: Arantes BBA 

PROVIDER: S-EPMC12194254 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature